|Position: Associate Professor, Department of Biomedical Sciences
Affiliation: University of Windsor
Area of Expertise: Drosophila Genetics, cell cycle regulation, Developmental Biology
Dr. Andrew Swan conducts research on the cell cycle, while studying its specific regulations and modification on the model organism Drosophila melanogaster. One main topic he focuses on is the SCF complex (Skp, Cullin, F-box containing complex); specifically, its role as a tumor suppressor in mitosis. The SCF complex used in experiments is ‘SCF-Skp2 ubiquitin ligase,’ which catalyzes the ubiquitination and destruction of specific proteins. The loss of Skp2 or protein Cks85A (Cyclin-dependent kinase subunit 85A) results in genome instability during cellular replication, allowing one to believe it has a tumour suppressive role in mitosis.
Dr. Swan’s most recent work focuses on determining the specific role these proteins play in genome stability by identifying proteins that interact with SCF-Skp2. An additional study of Dr. Swan’s lab pivots meiosis and embryogenesis, regarding how their divisions are regulated spatially and temporally. Meiosis is extremely complex compared to the division of embryogenesis (includes only S-phase and mitosis). Since these two processes are temporally similar, it is likely very complex regulators are involved. Dr. Swan is using female meiosis with embryonic divisions to find answers.
5 Selected Publications:
Bourouh, M., and Swan, A. (2018). Cell Cycle Regulators in Female Meiosis of Drosophila melanogaster. In Drosophila melanogaster, F. Perveen, ed. (IntechOpen), pp. 117-149.
Mehsen, H., Boudreau, V., Garrido, D., Bourouh, M., Larouche, M., Maddox, P.S., Swan, A., and Archambault, V. (2018). PP2A-B55 Promotes Nuclear Envelope Reformation after Mitosis in Drosophila. Journal of Cell Biology 217(12), 4106-4123.
Bourouh, M., Dhaliwal, R., Rana, K., Sinha, S., Guo, Z., and Swan, A. (2016) Disntinct and Overlapping Requirements for Cyclins A, B and B3 in Drosophila Female Meiosis. G3: Genes, Genomes, Genetics 6(11), 3711-3724.
Guo, Z., Batiha, O., Bourouh, M., Fifield, E., and Swan, A. (2016). Role of Securin, Separase and Cohesins in Female Meiosis and Polar Body Formation in Drosophila. Journal of Cell Science 129, 531-542.
Batiha, O., and Swan, A. (2012). Evidence That the Spindle Assembly Checkpoint Does Not Regulate APC(Fzy) Activity in Drosophila Female Meiosis. Genome 55(1), 63-67.