|Position: Associate Professor, Biomedical Sciences
Affiliation: University of Windsor
Area of Expertise:
The overall goal of our research program is to reveal central cellular decisions regulating cell growth and development to determine novel mechanisms regulating diseases such as cancer. The Hudson lab specifically focuses on the role of the Polo-like kinase family (Plks1-5) of proteins with respect to their role in malignancy, the cell cycle, DNA damage pathways and development. During his post-doctoral training Dr Hudson established the Plk4 transgenic knock-out mouse model. Plk4 null mice are embryonic lethal, while Plk4 heterozygous mice are haploinsufficient and develop liver, lung and other tumours at a high frequency. In general, aberrant expression of the individual Plks has been associated with numerous cancers.
5 Selected Publications:
Hooker, L.N., Smoczer, C., Abbott, S., Fakhereddin, M., Hudson, J.W., and Crawford, M.J. (2017). Xenopus pitx3 Targets Genes lhx1 and xnr5 are Identified Using a Novel Three-Fluor Flow Cytometry-Based Analysis of Promoter Activation and Repression. Developmental Dynamics, 246(9), 657-669.\
Warner, A.H., Guo, Z.H., Moshi, S., Hudson, J.W., and Kozarova, A. (2016). Study of Model Systems to Test the Potential Function of Artemia Group 1 Late Embryogenesis Abundant (LEA) proteins. Cell Stress Chaperones, 21(1), 139-154.
Ward, A., Sivakumar, G., Kanjeekal S., Hamm, C., Labute, B.C., Shum, D., and Hudson, J.W. (2015). The Deregulated Promoter Methylation of the Polo-like Kinases as a Potential Biomarker in Hematological Malignancies. Leukemia & Lymphoma, 56(7), 2123-2133.
Ward, A., and Hudson, J.W. (2014). p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress. PLOS ONE, 9(1).
Kozarova, A., Hudson, J.W., and Vacratsis, P.O. (2011). The Dual-Specificity Phosphatase hYVH1 (DUSP12) is a Novel Modulator of Cellular DNA Content. Cell Cycle, 10(10), 1669-1678.