Matthew Krause, Ph.D.

Position: Associate Professor
Affiliation: University of Windsor

E-mail: matthew.krause@uwindsor.ca

Website: www.uwindsor.ca/kinesiology/518/dr-matthew-kraus

Areas of Expertise: Mechanisms of Tissue Repair

Brief Description of Research:

Dr. Krause’s NSERC- and CIHR-funded research focuses on understanding the molecular and cellular regulation of tissue regeneration. A main area of interest for his team is how regeneration can be compromised in pathophysiological states such as cancer, diabetes, or aging. His primary research projects aim to identify the mechanisms underlying impaired regeneration of skin and skeletal muscle regeneration in specific disease states, and to develop novel interventions to improve regeneration.

5 Selected Publications:

Krause, M.P., Milne, K.J., and Hawke, T.J. (2019). Adiponectin-Consideration for its Role in Skeletal Muscle Health. International Journal of Molecular Sciences, 20(7).

Johnston, A.P., Yuzwa, S.A., Carr, M.J., Mahmud, N., Storer, M.A., Krause, M.P., Jones, K., Paul, S., Kaplan, D.R., and Miller, F.D. (2016) Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors are Required for Regeneration of the Mammalian Digit Tip. Cell Stem Cell, 19(4), 433-448.

Krause, M.P., Dworski, S., Feinberg, K., Jones, K., Johnston, A.P.W., Paul, S., Peles, E., Bagli, D., Kaplan, D.R. and Miller, F.D. (2014). Direct Genesis of Functional Rodent and Human Schwann Cells From Skin Mesenchymal Precursors. Stem Cell Reports. 3, 85-100.

Krause, M.P., Al-Sajee, D., D’Souza, D.M., Rebalka, I.A., Moradi, J., Riddell, M.C., Hawke, T.J. (2013). Impaired Macrophage and Satellite Cell Infiltration Occurs in a Muscle-Specific Fashion Following Injury in Diabetic Skeletal Muscle. PLoS One, 8(8).

Krause, M.P., Moradi, J., Nissar, A.N., Riddell, M.C., Hawke, T.J. (2011). Inhibition of Plasminogen Activator Inhibitor-1 (PAI-1) Restores Skeletal Muscle Regeneration in Untreated Diabetic Mice.  Diabetes. 60(7),1964-1972.