|Name: Prof. Dr. med. Frank Winkler
Areas of Expertise:
Position: Head of the Experimental Neurooncology Research Group
|Brief Description of Research:|
|Dr. Winkler earned his medical degree at Freiburg University. He completed a research fellowship at the Steele Lab at Harvard University in Boston, Massachusetts. Later, he received his assistant professor degree from Ludwig-Maximilian University, and became full professor (W3) in Heidelberg in 2012.
His work has been published in Nature, Nature Medicine, Neuro-Oncology, Clinical Cancer Research, Neurology, among others. Dr Winkler is involved in several phase 2 and 3 clinical studies.
The lab in the German Cancer Research Center (DKFZ) has a focus on intravital microscopy of cellular and molecular mechanisms of brain tumor progression, and how established and new therapies interfere with it.
Dr. Winkler’s lab recently discovered ultra-long membrane tubes (tumor microtubes, TMs) that are used by glioblastoma cells to invade and colonize the brain, and to form a large communicating and resistant multicellular network.
|5 Select Publications (trainees underlined):|
|Winkler F, Wick W. Harmful networks in the brain and beyond. Science. 2018 Mar 9;359(6380):1100-1101. doi: 10.1126/science.aar5555. PubMed PMID: 29590028.
Winkler F, Osswald M, Wick W. Anti-Angiogenics: Their Role in the Treatment of Glioblastoma. Oncol Res Treat. 2018;41(4):181-186. doi: 10.1159/000488258. Epub 2018 Mar 23. PubMed PMID: 29562225.
Weil S, Osswald M, Solecki G, Grosch J, Jung E, Lemke D, Ratliff M, Hänggi D, Wick W, Winkler F. Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas. Neuro Oncol. 2017 Oct 1;19(10):1316-1326. doi:10.1093/neuonc/nox070. PubMed PMID: 28419303; PubMed Central PMCID: PMC5596180.
Jung E, Osswald M, Blaes J, Wiestler B, Sahm F, Schmenger T, Solecki G, Deumelandt K, Kurz FT, Xie R, Weil S, Heil O, Thomé C, Gömmel M, Syed M, Häring P, Huber PE, Heiland S, Platten M, von Deimling A, Wick W, Winkler F. Tweety-Homolog 1 Drives Brain Colonization of Gliomas. J Neurosci. 2017 Jul 19;37(29):6837-6850. doi: 10.1523/JNEUROSCI.3532-16.2017. Epub 2017 Jun 12. PubMed PMID: 28607172.
Osswald M, Jung E, Sahm F, Solecki G, Venkataramani V, Blaes J, Weil S, Horstmann H, Wiestler B, Syed M, Huang L, Ratliff M, Karimian Jazi K, Kurz FT, Schmenger T, Lemke D, Gömmel M, Pauli M, Liao Y, Häring P, Pusch S, Herl V, Steinhäuser C, Krunic D, Jarahian M, Miletic H, Berghoff AS, Griesbeck O, Kalamakis G, Garaschuk O, Preusser M, Weiss S, Liu H, Heiland S, Platten M, Huber PE, Kuner T, von Deimling A, Wick W, Winkler F. Brain tumour cells interconnect to a functional and resistant network. Nature. 2015 Dec 3;528(7580):93-8. doi 1038/nature16071. Epub 2015 Nov 4. PubMed PMID: 26536111.