|Name: Eugene Wong
Position: Interim Director of Physics Research and Education
|Brief Description of Research:|
|My research is on understanding causes of cancer recurrences (local or distant) after undergoing radiotherapy as part of a definitive treatment and seek novel treatments to prevent such recurrences.
Our group perform longitudinal analyses on patient outcomes as well as experiments using small animal models. Specifically, for glioblastoma, we have established a multi-parametric response mapping (MPRM) method to longitudinal magnetic resonance imaging data for the prediction of survival1. Imaging residual diseases near the end of a course of radiotherapy was also performed in a cohort of glioma patients2. In addition, we have established a micro-CT based irradiation platform for targeted irradiation of small animals3. For example, we have a series of publications on cranial irradiation of a murine brain metastasis model4. Irradiation of orthotopic glioma models have also been initiated. Together with Drs. Hebb and Schmid, we are studying intratumoural modulation therapy5 in a small animal model intended for use as an adjuvant therapy to prevent glioma recurrence after definitive treatment with temozolomide and radiotherapy.
|5 Select Publications (trainees underlined):|
|1: Lausch A, Yeung TP, Chen J, Law E, Wang Y, Urbini B, Donelli F, Manco L, Fainardi E, Lee TY, Wong E. A generalized parametric response mapping method for analysis of multi-parametric imaging: A feasibility study with application to glioblastoma. Med Phys. 2017 Nov;44(11):6074-6084. doi: 10.1002/mp.12562. Epub 2017 Oct 13. PubMed PMID: 28875538.
2: Yeung TP, Yartsev S, Lee TY, Wong E, He W, Fisher B, VanderSpek LL, Macdonald D, Bauman G. Relationship of computed tomography perfusion and positron emission tomography to tumour progression in malignant glioma. J Med Radiat Sci. 2014 Feb;61(1):4-13. doi: 10.1002/jmrs.37. Epub 2014 Jan 16. PubMed PMID: 26229630; PubMed Central PMCID: PMC4175825.
3: Jensen MD, Hrinivich WT, Jung JA, Holdsworth DW, Drangova M, Chen J, Wong E. Implementation and commissioning of an integrated micro-CT∕RT system with computerized independent jaw collimation. Med Phys. 2013 Aug;40(8):081706. doi:10.1118/1.4812422. PubMed PMID: 23927303.
4: Zarghami N, Murrell DH, Jensen MD, Dick FA, Chambers AF, Foster PJ, Wong E. Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response. Radiat Oncol. 2018 Jun 1;13(1):104. doi: 10.1186/s13014-018-1028-8. PubMed PMID: 29859114; PubMed Central PMCID: PMC5984731.
5: Di Sebastiano AR, Deweyert A, Benoit S, Iredale E, Xu H, De Oliveira C, Wong E, Schmid S, Hebb MO. Preclinical outcomes of Intratumoral Modulation Therapy for glioblastoma. Sci Rep. 2018 May 8;8(1):7301. doi: 10.1038/s41598-018-25639-7. PubMed PMID: 29740075; PubMed Central PMCID: PMC5940838.