|Name: Robert Bartha
Areas of Expertise:
Position: Scientist and Director, Imaging Research Group
Position: Professor, Department of Medical Biophysics
|Brief Description of Research:|
|Dr. Robert Bartha is Professor of Medical Biophysics at Western University, with cross appointments in Medical Imaging and Psychiatry. He is also a Scientist and Director of the Imaging Research Laboratories at the Robarts Research Institute. His research has focused on the development of high-field magnetic resonance imaging and spectroscopy methods for the early diagnosis of disease and monitoring of treatment response; specifically related to neurodegeneration, cervical myelopathy, and brain cancer. Dr. Bartha specializes in ultra-high magnetic field imaging utilizing a 7 Tesla human MRI scanner, the only one of its kind in Canada, as well as 3 Tesla human and 9.4 Tesla small animal MRI scanners at the Western Centre for Functional and Metabolic Mapping. Dr. Bartha develops and validates specific imaging biomarkers of disease progression including MRI tracers that highlight specific pathological aspects of a disease process. Most recently, Dr. Bartha has developed methods for measuring intracellular pH in both animal models and humans, a method with exciting applications in neurological diseases including brain cancer. Using drugs already approved in humans, he can modulate intracellular pH monitored by pH weighted MRI, an approach that could be used to diagnose, stage, and treat various cancers. Dr. Bartha heads an exciting team that includes research associates, post-doctoral fellows, technicians, and students, with a broad range of expertise in imaging.|
|5 Select Publications (trainees underlined):|
|M Albatany, A Li, S Meakin, R Bartha. In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide. Journal of Clinical Oncology May 2018. [Epub ahead of print]. PubMed ID: 29749579.
M Albatany, A Li, S Meakin, R Bartha. Dichloroacetate induced intracellular acidification in glioblastoma: In-vivo detection using AACID-CEST MRI at 9.4 Tesla. Journal of Neuro-Oncology 136(2):255-262, January 2018. PubMed ID: 29143921.
K Marathe, N McVicar, A Li, M Bellyou, S Meakin, R Bartha. Topiramate induces acute intracellular acidification in gliobalastoma. Journal of Neuro-Oncology 130(3):465-472, December 2016. PubMed ID: 27613534.
N McVicar, AX Li, S Meakin, R Bartha. Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine. NMR in Biomedicine 28(5):566-575, May 2015. PubMed ID:25808190.
N McVicar, A Li, D Gonçalves, M Bellyou, S Meakin, M Prado, R Bartha. Quantitative tissue pH measurement during cerebral ischemia using amine and amide concentration-independent detection (AACID) with MRI. Journal of Cerebral Blood Flow and Metabolism 34(4):690-698, April 2014. PubMed ID: 244906171.