Stuart Smith

Stuart Smith Name: Stuart Smith

Areas of Expertise: Neurosurgical drug delivery, tumour heterogeneity, and biological effects of therapeutic electrical fields

Position: Clinical Associate Professor Neurosurgery
Affiliation: University of Nottingham

E-mail: stuart.smith@nottingham.ac.uk
Website: www.cbtrc.org

Brief Description of Research:

I am an academic Neurosurgeon whose research focuses on the malignant brain tumour Glioblastoma (GBM) which is a major cause of cancer related mortality in both children and adults. Tumour heterogeneity is a major contributor to treatment resistance, and we acquire multiple surgical targets from operated GBMs to investigate this genetic variety. We examine both gene expression, microRNA expression and levels of RNA methylation, seeking more effective ways of targeting molecular abnormalities in GBM. Another major factor in preventing adequate treatment of GBM is the Blood Brain Barrier and my group are involved with studies looking at ways of surgically implanting chemotherapy into the brain via biodegradable polymers and delivering electrical therapy to the brain more effectively.

5 Select Publications (trainees underlined):

Smith SJ, Tyler BM, Gould T, Veal GJ, Gorelick N, Rowlinson J, Serra R, Ritchie A, Berry P, Otto A, Choi J, Skuli N, Estevez-Cebrero M, Shakesheff KM, Brem H, Grundy RG, Rahman R. “Overall survival in orthotopic malignant glioma is significantly prolonged by neurosurgical delivery of combined etoposide and temozolomide from a thermo-responsive biodegradable paste”, Clinical Cancer Research, 2019 May 21. 25(16):5094-5106 doi: 10.1158/1078-0432.CCR-18-3850

Branter J, Basu S and Smith SJ. “Tumour treating fields in a combinatorial therapeutic approach”, Oncotarget, 2018 9(93):36631-36644. doi: 10.18632/oncotarget.26344

Smith SJ, Diksin M, Chhaya S, Sairam S, Estevez-Cebrero MA, Rahman R. “The invasive region of Glioblastoma defined by 5ALA guided surgery has an altered cancer stem cell marker profile compared to central tumour”, Int J Mol Sci, 2017 18, 2452 PMID 29156557

Smith SJ, Ward JH, Tan C, Grundy RG and Rahman R. “Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response”, Oncotarget, epub ahead of print June 2 2015 PMID: 26203665

Smith SJ*, Tilly H, Macarthur DC, Lowe J, Coyle B, Grundy RG. “CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma”, Acta Neuropathologica, 2012 124(1):99-110 PMID: 22311740