Tavarekere Nagaraja

Name: Taverekere N. Nagaraja, PhD
Position: Asst. Scientist
Affiliation: Dept. of Neurosurgery, Henry Ford Hospital, 2799 West Grand Blvd., Detroit, MI 48202. USA

E-mail: TNagara1@hfhs.org

Phone: +001 (313) 916-3853

Area of Expertise: Glioma vascular physiology; Brain-Tumor barrier


Brief Description of Research:
My career goals are to advance the understanding of cerebrovascular and neuronal function and dysfunction in neurological and metabolic diseases that affect the brain. From my graduate studies on effects of exposure to environmental neurotoxins on neurotransmitters and behavior, I have continued to work and publish in this field. For the past several years I have been part of a productive team that has investigated blood-brain barrier and blood-tumor barrier functioning using animal models for stroke, intra-cerebral hemorrhage and primary brain tumors. I have applied non-invasive magnetic resonance imaging (MRI), quantitative autoradiography, laser scanning confocal microscopy and neuropathology to tease out the responses of brain tissue under these disease conditions and after treatments. We have pioneered several investigations to measure brain responses using MRI and their concurrent confirmation using terminal gold standard techniques. This has led to first applications of MRI-based Patlak plot, Logan plot and tumor interstitial fluid pressure estimates. My lab has considerable expertise in brain tumor studies using animal models. Image acquisitions by MRI, bright field microscopy, fluorescence microscopy and 3-dimensional confocal microscopy are routinely done in my laboratory to understand the mechanisms of the functional processes being examined.


5 Select Publications (trainees underlined):
NAGARAJA TN, Aryal MP, Brown SL, Bagher-Ebadian H, Mikkelsen T, Yang JJ, Panda S, Keenan KA, Cabral G, Ewing JR. Cilengitide-induced temporal variations in transvascular transfer parameters of tumor vasculature in a rat glioma model: identifying potential MRI biomarkers of acute effects. PLoS One. 2013;8:e84493. PMC3871527

Ewing JR, NAGARAJA TN, Aryal MP, Keenan KA, Elmghirbi R, Bagher-Ebadian H, Panda S, Lu M, Mikkelsen T, Cabral G, Brown SL. Peritumoral tissue compression is predictive of exudate flux in a rat model of cerebral tumor: an MRI study in an embedded tumor. NMR Biomed. 2015;28:1557-69. PMCID: PMC4656050.

Elmghirbi R, NAGARAJA TN, Brown SL, Panda S, Aryal MP, Keenan KA, Bagher-Ebadian H, Cabral G, Ewing JR. Acute temporal changes of MRI-tracked tumor vascular parameters after combined anti-angiogenic and radiation therapies in a rat glioma model: identifying signatures of synergism. Radiation Research 2017;187:79-88. PMCID: PMC5381817

NAGARAJA TN, Elmghirbi R, Brown SL, Schultz LR, Lee IY, Keenan KA, Panda S, Cabral G, Mikkelsen T, Ewing JR. Reproducibility and relative stability in magnetic resonance imaging indices of tumor vascular physiology over a period of 24 h in a rat 9L gliosarcoma model. Magn Reson Imaging. 2017;44:131-139. PMID: 28887206

Elmghirbi R, NAGARAJA TN, Brown SL, Keenan KA, Panda S, Cabral G, Bagher-Ebadian H, Divine GW, Lee IY, Ewing JR. Toward a noninvasive estimate of interstitial fluid pressure by dynamic contrast-enhanced MRI in a rat model of cerebral tumor. Magn Reson Med. 2018 Mar 9. [Epub ahead of print] PMID: 29524243